Gluten-Free – the finished product contains no detectable gluten (<10ppm gluten)
No Detectable GMOs – the finished product contains no detectable genetically-modified organism
Vegetarian –Isotonix Vitamin K2 with D3 is a vegetarian product
Isotonic-capable Drinkable Supplements – easy-to-swallow supplements in liquid form are immediately available to the body for absorption
Why choose Isotonix Vitamin K2 with D3?
Isotonix Vitamin K2 with D3 contains vitamin K2, a form of vitamin K which supports calcium utilization, along with vitamin D3, the metabolically active form of vitamin D. Vitamin K supports the normal delivery of calcium to the bones, while vitamin D plays an important role in bone health, working with vitamin K to support normal absorption of calcium. Isotonix Vitamin K2 is the first of its kind to deliver both of these powerful vitamins with isotonic delivery. Vitamin K2 and D3 are paired together in Isotonix Vitamin K2 with D3 so they can work synergistically together to support calcium absorption and utilization. Two of the more common forms of vitamin K are K1 and K2. While there are many similarities between these two forms of vitamin K, they can be distinguished by their important differences, the most significant being their differing pharmacokinetic properties. Vitamin K1 disappears rapidly from the blood, while vitamin K2 persists in the blood’s circulation for a longer time.
Why the Isotonix® Delivery System is Great!
Isotonix Delivery System
Isotonix - the World's Most Advanced Nutraceuticals
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state. Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining great absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Vitamin K is a fat-soluble vitamin found in meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little vitamin K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health.
Vitamin D3 (Cholecalciferol)
Vitamin D is a fat-soluble vitamin that is found in some foods and produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth, and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors, such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with frail bones and muscle weakness.
Why are vitamins K and D included in Isotonix Vitamin K2 with D3?
Vitamins K and D are paired together due to their unique partnership. Vitamins K and D work together to promote healthy calcium absorption and utilization.
Is Isotonix Vitamin K2 with D3 safe for people on anti-coagulant medications?
Most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.
How do I take Isotonix Vitamin K2 with D3?
Mix one capful of Isotonix Vitamin K2 with D3 with 60 ml of water. Take one serving daily.
Is it safe to take more than 1 serving of this product daily?
One serving daily of Isotonix Vitamin K2 with D3 is recommended. Check with your health care practitioner before taking additional daily servings of this product.
What are dietary sources of vitamin D?
Foods rich in vitamin D include cod liver oil, salmon, mackerel and tuna.
- Adorini L. Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases. International Immunopharmacology. 2(7):1017-1028, 2002.
- Argiles A et al. Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients. Blood Purification. 20(4):370-375, 2002.
- Bekner K. The vitamin K-dependent carboxylase. Journal of Nutrition. 130(8):1877-1880, 2000.
- Binkley N et al. Vitamin K nutrition and osteoporosis. Journal of Nutrition. 125(7):1812-1821, 1995.
- Bischoff-Ferrari Het al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 293(18):2257-2264, 2005.
- Blackmore K et al. Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer. American Journal of Epidemiology. 168(8):915-24, 2008.
- Cantorna M et al. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Experimental Biology and Medicine (Maywood). 229(11):1136-1142, 2004.
- Cantorna M. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Society for Experimental Biology and Medicine. 223:230-233, 2000.
- Chapuy M et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
- Chlebowski R et al. Vitamin K in the treatment of cancer. Cancer Treatment Review. 12:49-63, 1985.
- Deluca H et al. Vitamin D: its role and uses in immunology. FASEB Journal. 15(14):2579-2585, 2001.
- Garber, A. K., et al. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. Journal of Nutrition. 129(6):1201-1203, 1999.
- Garland C et al. The role of vitamin D in cancer prevention. American Journal of Public Health. 96(2):252-61, 2006.
- Giovannucci E et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. Journal of the National Cancer Institute. 98(7):451-459, 2006.
- Gorham E et al. Vitamin D and prevention of colorectal cancer. Journal Steroid Biochemistry and Molecular Biology. 97(1-2):179-94, 2005.
- Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
- Grant W et al. Reviews: A critical review of studies on vitamin D in relation to colorectal cancer. Nutrition and Cancer. 48(2):115-123, 2004.
- Guirguis-Blake J et al. Oral vitamin D3 decreases fracture risk in the elderly. Journal of Family Practice. 52(6):431-435, 2003.
- Gundberg C et al. Vitamin K status and bone health: an analysis of methods for determination under carboxylated osteocalcin. Journal of Clinical Endocrinology and Metabolism. 83(9):3258-3266, 1998.
- Habu D et al. Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. JAMA. 292(3):358-361, 2004.
- Harris D et al. Vitamin D and colon carcinogenesis. Journal of Nutrition. 134(12):3463S-3471S, 2004.
- Hayes C et al. The immunological functions of the vitamin D endocrine system. Cellular and Molecular Biology. 49(2):277-300, 2003.
- Hidaka T et al. Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2). Journal of Bone and Mineral Metabolism. 20(4):235-239, 2002.
- Hiruma Y et al. Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. Biochemical Biophysical Research Communications. 314(1):24-30, 2004.
- Hitomi M et al. Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo. International Journal of Oncology. 26(3):713-720, 2005.
- Holick, M. Vitamin D: Its role in cancer prevention and treatment. Progress in Biophysics and Molecular Biology. 92(1):49-59, 2006.
- Iwamoto J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50. Review.
- Iwamoto J et al. Effects of vitamin K2 on osteoporosis. Current Pharmaceutical Design. 10(21):2557-2576, 2004.
- Kameda T et al. Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochemical and Biophysical Research Communications. 220(3):515-519, 1996.
- Knapen M et al. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International. 18(7):963-72, 2007.
- Kristal-Boneh E et al. Association of calcitriol and blood pressure in normotensive men. Hypertension. 30(5):1289-1294, 1997.
- Li Y et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. Journal of Clinical Investigation. 110(2):229-238, 2002.
- Li Y et al. Vitamin D regulation of the renin-angiotensin system. Journal of Cell Biochemistry. 88(2):327-331, 2003.
- Li Y et al. Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. Journal of Steroid Biochemistry and Molecular Biology. 89-90(1-5):387-392, 2004.
- Nelsestuen G et al. Vitamin K-dependent proteins. Vitamins and Hormones. 58:355-389, 2000.
- Neogi, T., et al. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis and Rheumatism. 54(4):1255-1261, 2006.
- Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition. 87:985-992, 2008.
- Nouso K et al. Regression of hepatocellular carcinoma during vitamin K administration. World Journal of Gastroenterology. 11(42):6722-6724, 2005.
- Pfeifer M et al. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. Journal of Clinical Endocrinology and Metabolism. 86(4):1633-1637, 2001.
- Plaza S and La
- Plaza S and La
- Price P. Role of vitamin K-dependent proteins in bone metabolism. Annual Review of Nutrition. 8:565-583, 1988.
- Schaafsma, A., et al. Vitamin D3 and vitamin K1 supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. European Journal of Clinical Nutrition. 54:626-631, 2000.
- Schleithoff S et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition. 83(4):754-759, 2006.
- Shearer M. Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Current Opinion in Clinical Nutrition and Metabolic Care. 3(6):433-438, 2000.
- Shiraki, M., et al. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. Journal of Bone & Mineral Research. 15:515-522, 2000.
- Sigmund C. Regulation of renin expression and blood pressure by vitamin D(3). Journal of Clinical Investigation. 110(2):155-156, 2002.
- Taira H et al. Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. Calcified Tissue International. 73(1):78-85, 2003.
- Trivedi Det al. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. British Medical Journal. 326(7387):469, 2003.
- Van den Berghe G et al. Bone turnover in prolonged critical illness: effect of vitamin D. Journal of Clinical Endocrinology and Metabolism. 88(10):4623-4632, 2003.
- Vasquez A et al. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Alternative Therapies. 10(5):28-38, 2004.
- Weber P. Management of osteoporosis: is there a role for vitamin K? International Journal for Vitamin and Nutrition Research. 67(5):350-6, 1997.
- Yokoyama T et al. Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines. International Journal of Oncology. 26(1):33-40, 2005.
- Yoshida T et al. Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. International Journal of Oncology. 23(3):627-632, 2003.
- Zitterman A et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? Journal of the American College of Cardiology. 41(1):105-112, 2003.
Love the taste. Love that it is so good for me, doubled dosed when I got a cold...cold only lasted 3 days,everyone else is going on 2nd week. makes my joints feel better too.
- Shop Consultant
Perfect solution for my daughter
My daughter was just tested for her Vitamin D levels and they were low, about 28 and her doctor wants them between 50 to 80. Prescribed 50,000 IUs 2 times per week, so I will be ordering a number of bottles and she'll be tested again in a couple of months. Hope it works as good as they say it does!
i love this product.
my consultant Elaine kohr introduced me to this product. it is so good and I am never without it.
- Shop Consultant
Isontonix Vitamin D for VDR Dene Defect
Now that the human genome is mapped, it's possible to unearth gene defects that affect health. I have a defect in the VDR gene which affects how I use vitamin D. I've suffered with fatigue, many URIs and pneumonia, depression, memory problems, breast cancer, IBS, PCOS and many more for 30 years. My D levels were tested and were always normal. The problem is that the D isn't getting into the cells, even though it's in the blood. Taking a pill helped, but this Isotonix D with K is a whole different animal--the Isontonic delivery makes the difference. I have my life back after years of sleepwalking!
- Shop Consultant
VDR Polymorphism Patients Must Try This!
I have a variant of the VDR gene that affects how I utilize vitamin D at mt cell receptors, regardless of what my vit D levels are in blood tests. This caused 30 years of unexplained chronic fatigue, memory issues, depression, & my IBS & PCOS could also be related. The bioavailable form of vit D in this product has changed my life. 'Gel cap' supplements helped, but never took me back to complete health, as this has. If you had your genes tested & do have an issue with the VDR gene, Isotonix vitamin D is for you. For those w/ polymorphisms on the MTHFR gene, (which I have as well) please give the Isotonix B Complex product a try. This provides the bioavailable forms of folate and B12 especially that will help when other supplements do not.